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대한구강악안면임프란트학회지 2018 ; 22 (2) : p.8~15

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비글견의 두개골 결손부에 이식한 동종골과 자가골의 치유 비교: 예비 동물 실험
Comparison of Healing of Allograft and Autogenous Bone Implanted in the Skull Defect of Beagle Dog: Preliminary Animal Study

저자 이중곤1 , 김상윤1 , 윤필영1 , 김영균1,2*
논문 종류 원저 전문 보기 22-2_1-8.pdf 22-2_1-8.pdf
Purpose: The purpose of this study was to evaluate the healing process after autogenous and
allogenous bone grafts for calvarial bone defects in beagles.
Materials and Methods: Two defects were formed in the skulls of two beagles and then grafted
with a freeze-dried bone allograft (Double-Oss) and an autogenous bone chip, respectively. The
clinical, radiographic, and histomorphometric examination results of the specimens taken 4 and 8
weeks after bone grafting were analyzed.
Results: The clinical, radiographic, and histological assessments revealed that 4 and 8 weeks after
transplant, the beagle that received an autogenous bone graft was more likely to have high new
bone formation than the beagle that had an allogenous bone. Four weeks after the transplant, the
proportions of new bone formation were 11.5% and 35.8% in the allogenous and autogenous bones,
respectively. Eight weeks after the transplant, the proportion of new bone formation with the
allogenous bone increased significantly to 41.4% but was still less than the 65.6% with the autogenous
bone.
Conclusion: The amount of new bone formation was smaller and the formation rate was slower
with allogenous bone graft than with autogenous bone graft.
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